Scientific Program – ISNI Congress

Day 1 | Sunday August 20

Sponsored by

GSNI DAY 1 - SUNDAY AUGUST 20
MORNING SESSION 8:30am - 10:15am
Chairs: Roberto Furlan (ESNI/ECTRIMS) & V. Wee Yong (ASNI) 8:30am-8:45am Opening Remarks V.Wee Yong (ASNI), Gianvito Martino (ESNI/ECTRIMS) & Roberto Furlan (ESNI/ECTRIMS) 8:45am-9:30am How the brain controls peripheral immune responses in health and disease Asya Rolls (Israel - ESNI) 9:30am-10:15am Clinical Research in Neuroimmunology Fabienne Brilot (Australia - APSNI)
Coffee Break \| 10:15am-10:45am
MORNING SESSION CONTINUES 10:45am - 12:15pm
Chairs: Tika Benveniste (ASNI) & Qiang Liu (APSNI) 10:45am-11:30am Neuroimmunology from MRI-neuropathology transcriptomics to human organoids Martina Absinta (Italy - ESNI) 11:30am-12:15pm Neuroimmunology of mood disorders Caroline Menard (Canada - ASNI)
Lunch Break \| 12:15pm-1:15pm
AFTERNOON SESSION 1:15pm - 2:45pm
Chairs: Judith Greer (APSNI) & Lucas Schirmer (ESNI/ECTRIMS) 1:15pm-2:00pm Transcriptomic discoveries for neuroimmunology Florent Ginhoux (Singapore - APSNI) 2:00pm-2:45pm Neuroimmunology of axonal regeneration Zigang He (USA - ASNI)
Coffee Break \| 2:45pm-3:15pm
AFTERNOON SESSION CONTINUES 3:15pm - 5:30pm
Chairs: Shalina Ousman (ASNI) & Roland Liblau (ESNI/ECTRIMS) 3:15pm-4:00pm Neuroimmunology of myelination and remyelination Veronique Miron (Canada - ASNI) 4:00pm-4:45pm Microglia – a field at its crossroads Rosa Paolicelli (Switzerland - ESNI)

Day 2 | Monday August 21

ISNI DAY 2 - MONDAY AUGUST 21
WELCOME & INTRODUCTION 8:00am - 8:30am
Welcome Remarks Luc Vallières (Canada) & LOC ISNI President Francisco Quintana (USA) Introduction: current challenges in Neuroimmunology Jack Antel (Canada)
PLENARY SESSION 1 8:30am - 10:00am
Neuroimmune interactions in neural development, cognition, and homeostasis Chairs: Oleg Butovsky (USA) & Serge Rivest (Canada) 8:30am-9:00am \| Microglia functions from development to neurodegeneration Florent Ginhoux (Singapore) 9:00am-9:30am \| Immunoception: central representation and regulation of immunity Asya Rolls (Israel) 9:30am-10:00am \| Unexpected interactions of the immune and nervous system - relevance for disease Frauke Zipp (Germany)
Coffee Break \| 10:00am-10:30am
MORNING BREAKOUT SESSIONS 10:30am - 12:00pm
Inflammation in neurodegenerative diseases Chairs: Li Gan (USA) & Serge Rivest (Canada) 10:30am-10:48am \| Gut neuroimmune interaction impacts brain synucleinopathy in Parkinson’s disease models Soyon Hong (UK) 10:48am-11:06am \| Decoding chronic inflammation in multiple sclerosis Martina Absinta (Italy) Oral Presentations 11:06am-11:24am \| #137 The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease Aurélie de Rus Jacquet (Canada) 11:24am-11:42am \| #154 Meningeal Lymphatics dysfunction disturbs cortical E/I balance Kyungdeok Kim (USA) 11:42am-12:00pm \| #51 A CD8 T cell signature in amyotrophic lateral sclerosis 4 Laura Campisi (USA)	Autoantibodies in neurological conditions Chairs: Luc Valliéres (Canada) & Roland Liblau (France) 10:30am-10:48am \| The B cell immunology underlying autoantibody-mediated CNS diseases Sarosh Irani (UK) 10:48am-11:06am \| Autoimmune encephalitis and dementia – new disease concepts Harald Prüss (Germany) 11:06am-11:24am \| The cow conundrum – Novel insights into antibody-mediated disease mechanisms in multiple sclerosis Stefanie Kuerten (Germany) Oral Presentations 11:24am-11:42am \| #197 The emerging spectrum of foetal acetylcholine receptor antibody-related disorders (FARAD) Angela Vincent (UK) 11:42am-12:00pm \| #276 Anti-Ganglioside (Complex) Antibodies In Patients From The International Guillain-Barré Syndrome Outcome Study Robin C. M. Thomma (the Netherlands)
Sponsored Lunch Break Symposium by EMD Serono - 12:00pm-1:00pm
EMD Serono Sponsored Symposium \| Evolving Concepts in Multiple Sclerosis Disease Progression: The impact of peripheral and centrally-driven neuroinflammation Click on title for more information 12:15pm-12:20pm Welcome Dr V. Wee Yong 12:20pm-12:30pm Neuropathological mechanisms in peripherally and centrally-derived inflammation in MS Dr. V. Wee Yong 12:30pm-12:40pm The evolving clinical course of MS and its impact on disability progression Dr Jiwon Oh 12:40pm-12:50pm Emerging fluid biomarkers of MS disease progression Dr. Raphael Schneider 12:50pm-1:00pm Audience Q&A Dr. V. Wee Yong & Faculty
AFTERNOON BREAKOUT SESSIONS 1:00pm - 3:00pm
Non-MS autoimmune diseases Chairs: Stefanie Kuerten (Germany) & Raphael Schneider (Canada) 1:00pm-1:15pm \| Waking up to the immunology of Narcolepsy type 1 Roland Liblau (France) 1:15pm-1:30pm \| Mechanisms governing autoantibody-mediated pathology in autoimmune neurologic diseases Kevin O'Connor (USA) 1:30pm-1:45pm \| Immunopathology of NMOSD and MOGAD Kazuo Fujihara (Japan) Oral Presentations 1:45pm-2:00pm \| #42 Autoantibody effector functions in MOGAD Soumya S. Yandamuri (USA) 2:00pm-2:15pm \| #337 Regulation of Th17 and B cells by interferon-gamma in a novel Neuromyelitis Optica Disease Spectrum Disorder animal model Gabriel Arellano (USA) 2:15pm-2:30pm \| #251 Pathogenic complement activation in myasthenia gravis depends on affinity matured autoantibodies with synergistic subunit specificities Sebastian Holdermann (Switzerland) 2:30pm-2:45pm \| #261 Single-cell phenotyping of B cells to investigate Rituximab response in patients with Myasthenia Gravis Jacopo Morroni (Italy) 2:45pm-3:00pm \| #3 The emerging role of autoreactive T cells in Guillain-Barré syndrome Lenka Súkeníková (Switzerland)	Psychoneuroimmunology Chairs: Jessica Deslauriers (Canada) & Frauke Zipp (Germany) 1:00pm-1:15pm \| Immune-Brain Interactions in Depression Scott Russo (USA) 1:15pm-1:30pm \| Sex-specific brain and gut barrier alterations underlie stress vulnerability vs resilience in mice and human depression Caroline Menard (Canada) 1:30pm-1:45pm \| Using circadian neuroimmunology to dissect molecular, cellular, and functional outcomes in health and disease Nader Ghasemlou (Canada) Oral Presentations 1:45pm-2:00pm \| #300 The presence of antibodies against muscarinic acetylcholine receptors in people with first episode psychosis predicts a worse clinical outcome at 12 months follow-up Judith Greer (Australia) 2:00pm-2:15pm \| #142 Interaction between a high fat diet and stress: effect on depression in relation to the gut microbiome-endocannabinoidome axis Giada Giorgini (Canada) 2:15pm-2:30pm \| Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge Micaël Carrier (Canada) 2:30pm-2:45pm \| #172 Psychological stress exacerbates immunoglobulin E-dependent chronic allergic skin inflammation via suppression of M2 macrophage-induced efferocytosis Soichiro Yoshikawa (Japan) 2:45pm-3:00pm \| #400 Neurovascular mitochondrial susceptibility impacts blood-brain barrier function and behavior Jorge Alvarez (USA)	Learning about Neuroimmunology through MS Sponsored by ACTRIMS Chairs: Jacqueline Quandt (Canada) & Burkhard Becher (Switzerland) 1:00pm-1:24pm \| An unexpected role of B cells in neuromyelitis optica Thomas Korn (Germany) 1:24pm-1:48pm \| Age-sensitive immune markers in multiple sclerosis: relation to biological sex and treatment response Catherine Larochelle (Canada) 1:48pm-2:12pm \| Decoding and targeting cell type-specific signatures underlying progressive neuroinflammation Lucas Schirmer (Germany) 2:12pm-2:36pm \| The Impact of Aging on Glia and Neuroinflammation: Implications for MS and EAE Benjamin Segal (USA) 2:36pm - 3:00pm \| Microglia in multiple sclerosis – pathogenesis and imaging Laura Airas (Finland)
ISNI KEYNOTE LECTURE 3:15pm - 4:15pm
The Dale McFarlin Lecture Chair: Jack Antel (Canada) Tackling Heterogeneity in Multiple Sclerosis: On Path to Precision Neuroimmunology Amit Bar-Or (USA)
POSTER SESSION 1 4:15pm - 6:15pm Autoantibodies in neurological conditions Immuno-neuro-oncology Inflammation in neurodegenerative diseases Non-MS autoimmune diseases Psychoneuroimmunology Biomarkers of neuroinflammation
Welcome Cocktail 6:15pm - 7:15pm

Day 3 | Tuesday August 22

ISNI DAY 3 - TUESDAY AUGUST 22
PLENARY SESSION 8:00am - 10:00am
Pathological mechanisms in autoimmune diseases of the nervous system Chairs: Christopher Power (Canada) & Thomas Korn (Germany) 8:00am-8:30am \| EBV-Mediated Molecular Mimicry in Multiple Sclerosis William H. Robison (USA) 8:30am-9:00am \| B cells, BAFF and CNS inflammation Jen Gommerman (Canada) 9:00am-9:30am \| Antibody Defined CNS Autoimmune Neurological Disorders: Discovery to Near Cure Sean Pittock (USA) 9:30am-10:00am \| New insights into how brain and periphery communicate Jonathan Kipnis (USA)
Coffee Break \| 10:00am-10:30am
MORNING BREAKOUT SESSIONS 10:30am - 12:00pm
Involvement of glial cells in neuroinflammation Chairs: Nathalie Arbour (Canada) & Michael Simons (Germany) 10:30am-10:48am \| Regulatory glial cell-cell interactions Francisco Quintana (USA) 10:48am-11:06am \| Insights from a unique model to study de novo myelination Zhigang He (USA) 11:06am-11:24am \| What is the role of reactive astrocytes in disease? Shane Liddelow (USA) Oral Presentations 11:24am-11:42am \| #116 Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis Cameron S. McAlpine (USA) 11:42am-12:00pm \| #9 Fibulin-2 impedes oligodendrogenesis through engaging the Notch signaling pathway Samira Ghorbani (Canada)	Influence of sex on neuroinflammation Chairs: Lisa Osborne (Canada) & Ari Waisman (Germany) 10:30am-10:48am \| Sex differences in microglial metabolism and implications for neural development Staci Bilbo (USA) 10:48am-11:06am \| Female sex exacerbates age-related changes in microglia Marina Lynch (Ireland) 11:06am-11:24am \| Adiposity interacts with female sex to promote T helper 1 inflammation and autoimmunity Shannon Dunn (Canada) 11:24am-11:42am \| Biological sex as a determinant in inflammatory T cell responses in chronic CNS autoimmunity Manu Rangachari (Canada) Oral Presentations 11:42am-12:00pm \| #305 Role of sex, gonadal hormones and dutasteride treatment on central and peripheral inflammation in a mouse model of Parkinson’s disease. Amandine Isenbrandt (Canada)
Lunch Break \| 12:00pm-1pm
AFTERNOON BREAKOUT SESSIONS 1:00pm - 3:00pm
Microglia in neural development, remodelling, and protection Chairs: Staci Bilbo (USA) & David Gosselin (Canada) 1:00pm-1:15pm \| Diverse macrophages sense and govern brain environment Takahiro Masuda (Japan) 1:15pm-1:30pm \| The many roles of microglia in the pathogenesis of neurodegeneration Rosa Paolicelli (Switzerland) 1:30pm-1:45pm \| Roles of dark microglia during normal brain development Marie-Eve Tremblay (Canada) 1:45pm-2:00pm \| Microglia are required for remyelination Jason Plemel (Canada) Oral Presentations 2:00pm-2:15pm \| #289 Avb8-Tgfb1 signaling in brain vascular and microglial development Gabriel L. McKinsey (USA) 2:15pm-2:30pm \| #128 Stearoyl-CoA desaturase-1 impairs the regenerative and anti-inflammatory properties of microglia and T cells in the brain Jeroen F.J. Bogie (Belgium) 2:30pm-2:45pm \| #17 APOE4 Impairs Microglia Response to Neurodegeneration in Alzheimer’s Disease Neta Rosenzweig (USA) 2:45pm-3:00pm \| #83 Microglia coordinate cellular interactions during spinal cord repair in mice Faith H. Brennan (Canada)	T cells in neurological diseases Chairs: Shannon Dunn (Canada) & Manu Rangachari (Canada) 1:00pm-1:15pm \| Stranger Things about IL-12 and IL-23 Burkhard Becher (Switzerland) 1:15pm-1:30pm \| Th17 cells- to be, or not be, is the question before us Vijay Kuchroo (USA) 1:30pm-1:45pm \| IL-17 controls CNS autoimmunity through the intestinal microbiome Ari Waisman (Germany) Oral Presentations 1:45pm-2:00pm \| #11 TCF1 is a determinant of homeostatic versus pathogenic Th17 cell state Ana C. Anderson (USA) 2:00pm-2:15pm \| #193 Tissue-resident memory T cells sustain the chronic phase of experimental autoimmune encephalomyelitis Frederick Masson (France) 2:15pm-2:30pm \| #16 Brain endothelial antigen presentation detains CD8 T cells at the blood-brain barrier and contributes to its breakdown Javier Pareja (Switzerland) 2:30pm-2:45pm \| #355 Impaired CNS Immunosurveillance by CCR7+ CD4 T cells during chronic neuroinflammation Elizaldi Sonny (USA) 2:45pm-3:00pm \| #102 The transcription factor c-Maf promotes immunoregulation of CD8+ T cells in multiple sclerosis Norio Chihara (Japan)	Biomarkers of neuroinflammation Chairs: Catherine Larochelle (Canada) & Martina Absinta (Italy) 1:00pm-1:15pm \| Compartment specific (endo)phenotyping of neuroinflammation Heinz Wiendl (Germany) 1:15pm-1:30pm \| Biomarkers of relapsing course in MOG antibody-associated disease Fabienne Brilot (Australia) 1:30pm-1:45pm \| What Information Does the Serum Biomarker Neurofilament Light Chain Offer in the Management of Multiple Sclerosis? Mark Freedman (Canada) Oral Presentations 1:45pm-2:00pm \| #59 CanProCo Study; Examining Prognostic Protein Biomarkers in Sera and Plasma from Multiple Sclerosis Patients Fiona Tea (Canada) 2:00pm-2:15pm \| #286 Machine learning identifies a combination of immunological and clinical parameters as the best predictor of MS disease progression Stephanie Zandee (Canada) 2:15pm-2:30pm \| #266 Biomarkers in autoimmune diseases of the central nervous system : the autoimmune encephalitis challenge Chloe Bost (France) 2:30pm-2:45pm \| #310 Interleukin-7 receptor alpha is increased on CD4+ effector T cells in clinically established multiple sclerosis Raphael Schneider (Canada) 2:45pm-3:00pm \| #319 Immunosenescence trajectories in diverse human populations: evaluation of immune age towards personalized therapies Hanane Touil (USA)	Learning about neuroimmunology through Parkinson's disease - Sponsored by ASAP Chairs: John Lukens (USA) & Michael Heneka (Germany) 1:00pm-1:24pm \| Parkinson’s Disease-proteins regulate the transition from innate to adaptive immunity Michel Desjardins (Canada) 1:24pm-1:48pm \| Innate Immune Dysfunction in People with Parkinson’s and Pre-clinical Models of disease Malu Tansey (USA) 1:48pm-2:12pm \| Unveiling the Enigma: Exploring Neuroinflammation's Impact on Parkinson's Disease Ted Dawson (USA) 2:12pm-2:36pm \| Microglia iron overload and ferroptosis cause neurodegeneration Timothy Hammond (USA) 2:36pm-3:00pm \| Brain-to-gut trafficking of alpha-Synuclein by CD11c+ macrophages in Parkinson’s Disease Rhonda McFleder (Germany)
ISNI KEYNOTE LECTURE 3:15pm - 4:15pm
The Rita Levi-Montalcini Neurobiology Lecture Chair: Alexandre Prat (Canada) Inflammation and Neurodegeneration in multiple sclerosis: A single and common pathway? Hans Lassmann (Austria)
POSTER SESSION 2 4:15pm - 6:15pm Biomarkers of neuroinflammation Influence of sex on neuroinflammation Involvement of glial cells in neuroinflammation Microglia in neural development, remodelling, and protection Neuroimmunology general I T cells in Neurological diseases
ISNI GENERAL ASSEMBLY 6:15pm - 7:15pm

Day 4 | Wednesday August 23

ISNI DAY 4 \| WEDNESDAY AUGUST 23
PLENARY SESSION 8:00am - 10:00am
Neuroinflammation in degenerative diseases Chairs: Malu Tansey (USA) & Jean-Pierre Julien (Canada) 8:00am-8:30am \| TBD Michael Heneka (Germany) 8:30am-9:00am \| Neuroimmune modulation by AD risk genes Li Gan (USA) 9:00am-9:30am \| Honing in on the molecular orchestrators of neuroprotective microglial responses in Alzheimer’s disease John R. Lukens (USA) 9:30am-10:00am \| Brain-Immune ecosystem and immunotherapy to defeat dementia Michal Schwartz (Israel)
Coffee Break 10:00am-10:30am
MORNING BREAKOUT SESSIONS 10:30am - 12:00pm
CNS barriers Chairs: Britta Engelhardt (Switzerland) & Jorge Alvarez (USA) 10:30am-10:48am \| Regulation of the blood-brain barrier in health and disease Richard Daneman (USA) 10:48am-11:06am ! Ependymal cell dysregulation during neuroinflammatory events Jo Anne Stratton (Canada) 11:06am-11:24am \| Brain endothelial cells under inflammatory challenge Alexandre Prat (Canada) Oral Presentations 11:24am-11:42am \| #243 Cerebral microangiopathy is a key mediator of interferon-alpha neurotoxicity Barney Viengkhou (Australia) 11:42am-12:00pm \| #127 CRTAM-Necl2 interaction at the glia limitans triggers astrogliosis and protection against EAE Bieke Broux (Belgium)	Infection and neuroinflammation Chairs: Louis Flamand (Canada) & William Robinson (USA) 10:30am-10:48am \| Innate immune mechanisms in neurological disease: lessons from neuroHIV and COVID-19 Christopher Power (Canada) 10:48am-11:06am \| Mononuclear Cell Triggers of Learning and Memory Impairment : Viral effects on Integrated Systems Robyn Klein (USA) 11:06am-11:24am \| B cell dynamics during murine neurotropic coronavirus infection Cornelia Bergmann (USA) Oral Presentations 11:24am-11:42am \| #64 Trichinella spiralis promotes neuroimmune remodeling that ameliorates disease in a mouse model of multiple sclerosis Naomi M. Fettig (Canada) 11:42am-12:00pm \| #330 Sepsis, complement, and microglial synaptic pruning: findings in the mouse and human brain Kate A. Giffin (USA)
Lunch Break & Novartis Sponsored Symposium (starts at 12:15pm) 12:00pm-1:00pm
Novartis Sponsored Symposium \| From the Bedside to the Bench... and Back Again! Chair: Dr. Catherine Larochelle (Canada) Dr Amit Bar-Or (USA) Dr. Virginia Devonshire (Canada)
AFTERNOON BREAKOUT SESSIONS 1:00pm - 3:00pm
From basic to translational and clinical Neuroimmunology: contributions from young scientists - sponsored by JNI Chairs: Veit Rothhammer (Germany), Aakanksha Dixit (Australia), Jeff Dong (Canada), Naomi Habib (Israel), Hedwich Kuipers (Canada), Olga Rojas (Canada) & Michal Wheeler (USA) 1:00pm-1:15pm \| Introduction ISNI Young Committee & JNI 1:15pm-1:30pm \| The road not taken - cellular cascades in Alzheimer’s and aging Noami Habib (Israel) 1:30pm-1:45pm \| Protective glia crosstalk in autoimmune CNS inflammation Lena Lößlein (Germany) 1:45pm-2:00pm \| Impaired central tolerance characterises the early emergence of AQP4-specific B cells in neuromyelitis optica spectrum disorder Sudarshini Ramanathan (Australia) 2:00pm-2:15pm \| Immune regulation of stress Chao Wang (Canada) 2:15pm-2:30pm \| Understanding the role of B cells in neurodegeneration Olga Rojas (Canada) 2:30pm-2:45pm \| The neural circuits controlling sickness behavior Jessica Osterhout (USA) 2:45pm-3:00pm \| Discussion	Peripheral Neuroimmunology Chairs: Nader Ghasemlou (Canada) & Phillip Popovich (USA) 1:00pm-1:15pm \| Nociceptor neuron recognition of microbes in host defense and immunity Isaac Chiu (USA) 1:15pm-1:30pm \| Pain neurons control cancer immunosurveillance Sebastien Talbot (Canada) 1:30pm-1:45pm \| Neuro-immune interactions in the gut Daniel Mucida (USA) Oral Presentations 1:45pm-2:00pm \| 13 Multimodal control of dendritic cell functions by nociceptors Pavel Hanč (USA) B cells in Neuroinflammation Chairs: Amit Bar-Or (USA) & Heinz Wiendl (Germany) 2:00pm-2:15pm \| Plasmablasts in a model of CNS autoimmunity: from biology to therapy Luc Vallières 2:15pm-2:30pm \| #345 T:B cell communication in ectopic lymphoid follicles in CNS autoimmunity Anneli Peters (Germany) 2:30pm-2:45pm \| #44 T-bet+ Memory B Cells Induce Disease Relapses in Experimental Autoimmune Encephalomyelitis Rajiv Jain (Canada) 2:45pm-3:00pm \| #55 B cell depletion with anti-CD20 promotes neuroprotection in a BAFF-dependent manner in mice Angela A. Wang (Canada)	Learning about Neuroimmunology through ALS - Sponsored by ALS Society of Quebec Chairs: Chrstine Vande Velde (Canada) & Jean-Pierre Julien (Canada) 1:00pm-1:20pm \| The title of my talk will be: Microglia and macrophages for ALS progression. Séverine Boillée (France) 1:20pm-1:40pm \| Modulating myeloid cells in ALS by targeting α5 integrin Bahareh Ajami (USA) 1:40pm-2:00pm \| Targeting innate immune genes translation in ALS Jasna Kriz (Canada) 2:00pm-2:20pm \| Peripheral and resident immune cells crosstalk in ALS Cristina Limatola (Italy) 2:20pm-2:40pm \| Role of endogenous retroviruses in Amyotrophic Lateral Sclerosis Avindra Nath (USA) 2:40pm-3:00pm \| Restoring glial functions at the neuromuscular synapse: a clinical target in ALS Richard Robitaille (Canada)
ISNI KEYNOTE LECTURE 3:15pm - 4:15pm
The Immunology Lecture Chair: Francisco Quintana (USA) Checkpoints of CNS autoimmunity: from the perspective of an autoaggressive T cell Alexander Flügel (Germany)
POSTER SESSION 3 4:15pm - 6:15pm CNS barriers CNS-infiltrating innate immune cells Emerging therapies for neuroinflammatory conditions Infection and neuroinflammation Influence of diet and microbiota on neuroinflammation Neuroimmunology general II Novel approaches for neuroimmunologists

Day 5 | Thursday August 24

ISNI DAY 5 - THURSDAY AUGUST 24
PLENARY SESSION 8:00am - 10:00am
Neuroinflammation in neural injury and repair Chairs: Susanna Rosi (USA) & V. Wee Yong (Canada) 8:00am-8:30am \| Innate immune remodeling of damaged CNS barriers Dorian McGavern (USA) 8:30am-9:00am \| Innate immune mechanisms in remyelination Mikael Simons (Germany) 9:00am-9:30am \| Microglia regulation of myelin health across the lifespan Veronique Miron (Canada) 9:30am-10:00am \| Role of microglia and IL-6 signalling following brain injury Jana Vukovic (Australia)
Coffee Break 10:00am-10:30am
MORNING BREAKOUT SESSIONS 10:30am - 12:00pm
Emerging therapies for neuroinflammatory conditions Chairs: Benjamin Segal (USA) & Jack Antel (Canada) 10:30am-10:48am \| Overcoming CNS fibrosis for neuroregeneration V. Wee Yong (Canada) 10:48am-11:06am \| Xenon gas treatment to restore microglial functions in neurodegenerative diseases Oleg Butovsky (USA) Oral Presentations 11:06am-11:24am \| #340 Peptide-coupled RBCs as treatment for autoimmune diseases – dissecting the mechanisms of immune tolerance induction Vasileia Kalaitzaki (Switzerland) 11:24am-11:42am \| #156 Targeting the Inflammasome in Inflammaging Brianna Cyr (USA) 11:42am-12:00pm \| #299 Nasal anti-CD3 mAb induces Tregs that dampen microglial activation and treat neuroinflammatory diseases including MS, AD and ALS Howard Weiner (USA)	Influence of diet and microbiota on neuroinflammation Chairs: Jen Gommerman (Canada) & Takashi Yamamura (Japan) 10:30am-10:45am \| Microbial Contributions to Neurodevelopmental Disorders Kathy McCoy (Canada) 10:45am-11:00am \| Bringing it all together: How do genes, diet and the microbiome contribute to MS? Sergio Baranzini (USA) 11:00am-11:15am \| Specificity in the dietary fiber-microbiome-immune axis regulates susceptibility to neuroinflammation Lisa Osborne (Canada) Oral Presentations 11:15am-11:30am \| #121 Ketogenic diet promotes social stress resistance and modifies microglial morphology and ultrastructure in male mice Fernando González Ibánez (Canada) 11:30am-11:45am \| #284 Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis Theresa Montgomery (USA) 11:45am-12:00pm \| #119 Regulation of the antiviral immune response by the sensory nervous system Anais Roger (France)
Lunch Break 12:00pm - 1:00pm
AFTERNOON BREAKOUT SESSIONS 1:00pm - 2:30pm
CNS-infiltrating innate immune cells Chairs: Shalina Ousman (Canada) & Soheila Karimi (Canada) 1:00pm-1:15pm \| Brain engrafted macrophages and brain injury Susanna Rosi (USA) 1:15pm-1:30pm \| TBD Philip Popovich (USA) 1:30pm-1:45pm \| Cytokines produced by tissue-infiltrating innate immune cells as mediators of pain in chronic autoimmune diseases Steve Lacroix (Canada) Oral Presentations 1:45pm-2:00pm \| #124 Essential cytokines driving macrophage effector phenotypes in neuroinflammation Clara de la Rosa (Germany) 2:00pm-2:15pm \| #140 Lipid metabolism directs the phenotype of foamy phagocytes in multiple sclerosis lesions Jerome JA Hendriks (Belgium) 2:15pm-2:30pm \| #56 Depletion of leptomeningeal neutrophils ameliorates age-dependent grey matter demyelination Michelle Zuo (Canada)	Immuno-neuro-oncology Chairs: Alexandre Prat (Canada) & Francisco Quintana (USA) 1:00pm-1:15pm \| Decoding function and phenotype of brain tumor infiltrating T cells Michael Platten (Germany) 1:15pm-1:30pm \| The Role of Astrocytes in Glioblastoma Pathogenicity Lior Mayo (Israel) 1:30pm-1:45pm \| Spatial diversity of T cell response in malignant CNS tumors Dieter Henrik Heiland (Germany) 1:45pm-2:00pm \| Myeloid heterogeneity and functions in brain tumors Dolores Hambardzumyan (USA) Oral Presentations 2:00pm-2:15pm \| #285 Antiviral T cells populate glioblastoma and originate from pre-existing brain resident memory T cells Sierra Kleist (USA) 2:15pm-2:30pm \| #180 Analysis of factors that limit immunogenicity of intracranial melanomas Katarzyna Stasiak (USA)	Novel approaches for neuroimmunologists Chairs: Jasna Kriz (Canada) & Sergio Baranzini (USA) 1:00pm-1:15pm \| Human microglia in health and disease Bart Eggen (the Netherlands) 1:15pm-1:30pm \| Decoding the causal chain of glial activation in Alzheimer resolves the heterogeneity of the aging brain Philip L. De Jager (USA) Oral Presentations 1:30pm-1:45pm \| #126 Multidimensional single-cell analysis of meningeal inflammation and cortical microglia in progressive multiple sclerosis Carla Rodriguez-Mogeda (The Netherlands) 1:45pm-2:00pm \| #41 Classifying flow cytometry data using bayesian analysis helps to distinguish ALS patients from healthy controls Saskia Räuber (Germany) 2:00pm-2:15pm \| #274 Development of a Human Microglia Engraftment Model for the Study of Neurodegenerative and Neuroinflammatory Diseases Ashley Munie Gardner (USA) 2:15pm-2:30pm \| #322 Comparative analysis of methods to reduce activation signature gene expression in peripheral blood mononuclear cells Adam MacDonald (Canada)
ISNI KEYNOTE LECTURE 2:30pm - 3:30pm
The John Newsom-Davis Lecture Chair: Angela Vincent (UK) Axo-glial interactions in myelination and remyelination Catherine Lubetzki (France)
MID-CAREER AWARD 3:30pm - 4:15pm
We Are Neuroimmunology ISNI Mid-Career Award Chair: Fabienne Brilot (Australia) 3:30pm-3:45pm \| Introduction Fabienne Brilot (Australia) 3:45pm-4:00pm \| Keeping the balance: T cells, environment & disease Markus Kleinewietfeld (Belgium) 4:00pm-4:15pm \| The Dilemmas of Encephalitis Michael Wilson (USA)
CLOSING SESSION 4:15pm - 4:45pm

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