ISNI DAY 5 - THURSDAY AUGUST 24

PLENARY SESSION


8:00am - 10:00am
Neuroinflammation in neural injury and repair
Chairs: Susanna Rosi (USA) & V. Wee Yong (Canada)

8:00am-8:30am | Innate immune remodeling of damaged CNS barriers
Dorian McGavern (USA)

8:30am-9:00am | Innate immune mechanisms in remyelination
Mikael Simons (Germany)

9:00am-9:30am | Microglia regulation of myelin health across the lifespan
Veronique Miron (Canada)

9:30am-10:00am | Role of microglia and IL-6 signalling following brain injury
Jana Vukovic (Australia)
Coffee Break 10:00am-10:30am

MORNING BREAKOUT SESSIONS


10:30am - 12:00pm
Emerging therapies for neuroinflammatory conditions
Chairs: Benjamin Segal (USA) & Jack Antel (Canada)

10:30am-10:48am | Overcoming CNS fibrosis for neuroregeneration
V. Wee Yong (Canada)

10:48am-11:06am | Xenon gas treatment to restore microglial functions in neurodegenerative diseases
Oleg Butovsky (USA)

Oral Presentations
11:06am-11:24am | #340 Peptide-coupled RBCs as treatment for autoimmune diseases – dissecting the mechanisms of immune tolerance induction
Vasileia Kalaitzaki (Switzerland)

11:24am-11:42am | #156 Targeting the Inflammasome in Inflammaging
Brianna Cyr (USA)

11:42am-12:00pm | #299 Nasal anti-CD3 mAb induces Tregs that dampen microglial activation and treat neuroinflammatory diseases including MS, AD and ALS
Howard Weiner (USA)		Influence of diet and microbiota on neuroinflammation
Chairs: Jen Gommerman (Canada) & Takashi Yamamura (Japan)

10:30am-10:45am | Microbial Contributions to Neurodevelopmental Disorders
Kathy McCoy (Canada)

10:45am-11:00am | Bringing it all together: How do genes, diet and the microbiome contribute to MS?
Sergio Baranzini (USA)

11:00am-11:15am | Specificity in the dietary fiber-microbiome-immune axis regulates susceptibility to neuroinflammation
Lisa Osborne (Canada)

Oral Presentations
11:15am-11:30am | #121 Ketogenic diet promotes social stress resistance and modifies microglial morphology and ultrastructure in male mice
Fernando González Ibánez (Canada)

11:30am-11:45am | #284 Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis
Theresa Montgomery (USA)

11:45am-12:00pm | #119 Regulation of the antiviral immune response by the sensory nervous system
Anais Roger (France)
Lunch Break 12:00pm - 1:00pm

AFTERNOON BREAKOUT SESSIONS


1:00pm - 2:30pm
CNS-infiltrating innate immune cells Chairs: Shalina Ousman (Canada) & Soheila Karimi (Canada)

1:00pm-1:15pm | Brain engrafted macrophages and brain injury
Susanna Rosi (USA)

1:15pm-1:30pm | TBD
Philip Popovich (USA)

1:30pm-1:45pm | Cytokines produced by tissue-infiltrating innate immune cells as mediators of pain in chronic autoimmune diseases
Steve Lacroix (Canada)

Oral Presentations
1:45pm-2:00pm | #124 Essential cytokines driving macrophage effector phenotypes in neuroinflammation
Clara de la Rosa (Germany)

2:00pm-2:15pm | #140 Lipid metabolism directs the phenotype of foamy phagocytes in multiple sclerosis lesions
Jerome JA Hendriks (Belgium)

2:15pm-2:30pm | #56 Depletion of leptomeningeal neutrophils ameliorates age-dependent grey matter demyelination
Michelle Zuo (Canada)		Immuno-neuro-oncology
Chairs: Alexandre Prat (Canada) & Francisco Quintana (USA)

1:00pm-1:15pm | Decoding function and phenotype of brain tumor infiltrating T cells
Michael Platten (Germany)

1:15pm-1:30pm | The Role of Astrocytes in Glioblastoma Pathogenicity
Lior Mayo (Israel)

1:30pm-1:45pm | Spatial diversity of T cell response in malignant CNS tumors
Dieter Henrik Heiland (Germany)

1:45pm-2:00pm | Myeloid heterogeneity and functions in brain tumors
Dolores Hambardzumyan (USA)

Oral Presentations
2:00pm-2:15pm | #285 Antiviral T cells populate glioblastoma and originate from pre-existing brain resident memory T cells
Sierra Kleist (USA)

2:15pm-2:30pm | #180 Analysis of factors that limit immunogenicity of intracranial melanomas
Katarzyna Stasiak (USA)
Novel approaches for neuroimmunologists
Chairs: Jasna Kriz (Canada) & Sergio Baranzini (USA)

1:00pm-1:15pm | Human microglia in health and disease
Bart Eggen (the Netherlands)

1:15pm-1:30pm | Decoding the causal chain of glial activation in Alzheimer resolves the heterogeneity of the aging brain
Philip L. De Jager (USA)

Oral Presentations
1:30pm-1:45pm | #126 Multidimensional single-cell analysis of meningeal inflammation and cortical microglia in progressive multiple sclerosis
Carla Rodriguez-Mogeda (The Netherlands)

1:45pm-2:00pm | #41 Classifying flow cytometry data using bayesian analysis helps to distinguish ALS patients from healthy controls
Saskia Räuber (Germany)

2:00pm-2:15pm | #274 Development of a Human Microglia Engraftment Model for the Study of Neurodegenerative and Neuroinflammatory Diseases
Ashley Munie Gardner (USA)

2:15pm-2:30pm | #322 Comparative analysis of methods to reduce activation signature gene expression in peripheral blood mononuclear cells
Adam MacDonald (Canada)

ISNI KEYNOTE LECTURE


2:30pm - 3:30pm
The John Newsom-Davis Lecture
Chair: Angela Vincent (UK)

Axo-glial interactions in myelination and remyelination
Catherine Lubetzki (France)

MID-CAREER AWARD


3:30pm - 4:15pm
We Are Neuroimmunology ISNI Mid-Career Award
Chair: Fabienne Brilot (Australia)

3:30pm-3:45pm | Introduction
Fabienne Brilot (Australia)

3:45pm-4:00pm | Keeping the balance: T cells, environment & disease
Markus Kleinewietfeld (Belgium)

4:00pm-4:15pm | The Dilemmas of Encephalitis
Michael Wilson (USA)

CLOSING SESSION


4:15pm - 4:45pm