ISNI DAY 2 - MONDAY AUGUST 21

WELCOME & INTRODUCTION


8:00am - 8:30am
Welcome Remarks
Luc Vallières (Canada) & LOC
ISNI President Francisco Quintana (USA)

Introduction: current challenges in Neuroimmunology
Jack Antel (Canada)

PLENARY SESSION 1


8:30am - 10:00am
Neuroimmune interactions in neural development, cognition, and homeostasis
Chairs: Oleg Butovsky (USA) & Serge Rivest (Canada)

8:30am-9:00am | Microglia functions from development to neurodegeneration
Florent Ginhoux (Singapore)

9:00am-9:30am | Immunoception: central representation and regulation of immunity
Asya Rolls (Israel)

9:30am-10:00am | Unexpected interactions of the immune and nervous system - relevance for disease
Frauke Zipp (Germany)
Coffee Break | 10:00am-10:30am

MORNING BREAKOUT SESSIONS


10:30am - 12:00pm
Inflammation in neurodegenerative diseases
Chairs: Li Gan (USA) & Serge Rivest (Canada)

10:30am-10:48am | Gut neuroimmune interaction impacts brain synucleinopathy in Parkinson’s disease models
Soyon Hong (UK)

10:48am-11:06am | Decoding chronic inflammation in multiple sclerosis
Martina Absinta (Italy)

Oral Presentations
11:06am-11:24am | #137 The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease
Aurélie de Rus Jacquet (Canada)

11:24am-11:42am | #154 Meningeal Lymphatics dysfunction disturbs cortical E/I balance
Kyungdeok Kim (USA)

11:42am-12:00pm | #51 A CD8 T cell signature in amyotrophic lateral sclerosis 4
Laura Campisi (USA)		Autoantibodies in neurological conditions
Chairs: Luc Valliéres (Canada) & Roland Liblau (France)

10:30am-10:48am | The B cell immunology underlying autoantibody-mediated CNS diseases
Sarosh Irani (UK)

10:48am-11:06am | Autoimmune encephalitis and dementia – new disease concepts
Harald Prüss (Germany)

11:06am-11:24am | The cow conundrum – Novel insights into antibody-mediated disease mechanisms in multiple sclerosis
Stefanie Kuerten (Germany)

Oral Presentations
11:24am-11:42am | #197 The emerging spectrum of foetal acetylcholine receptor antibody-related disorders (FARAD)
Angela Vincent (UK)

11:42am-12:00pm | #276 Anti-Ganglioside (Complex) Antibodies In Patients From The International Guillain-Barré Syndrome Outcome Study
Robin C. M. Thomma (the Netherlands)
Sponsored Lunch Break Symposium by EMD Serono - 12:00pm-1:00pm
EMD Serono Sponsored Symposium | Evolving Concepts in Multiple Sclerosis Disease Progression: The impact of peripheral and centrally-driven neuroinflammation
Click on title for more information

12:15pm-12:20pm Welcome
Dr V. Wee Yong

12:20pm-12:30pm Neuropathological mechanisms in peripherally and centrally-derived inflammation in MS
Dr. V. Wee Yong

12:30pm-12:40pm The evolving clinical course of MS and its impact on disability progression
Dr Jiwon Oh

12:40pm-12:50pm Emerging fluid biomarkers of MS disease progression
Dr. Raphael Schneider

12:50pm-1:00pm Audience Q&A
Dr. V. Wee Yong & Faculty

AFTERNOON BREAKOUT SESSIONS


1:00pm - 3:00pm
Non-MS autoimmune diseases
Chairs: Stefanie Kuerten (Germany) & Raphael Schneider (Canada)

1:00pm-1:15pm | Waking up to the immunology of Narcolepsy type 1
Roland Liblau (France)

1:15pm-1:30pm | Mechanisms governing autoantibody-mediated pathology in autoimmune neurologic diseases
Kevin O'Connor (USA)

1:30pm-1:45pm | Immunopathology of NMOSD and MOGAD
Kazuo Fujihara (Japan)

Oral Presentations
1:45pm-2:00pm | #42 Autoantibody effector functions in MOGAD
Soumya S. Yandamuri (USA)

2:00pm-2:15pm | #337 Regulation of Th17 and B cells by interferon-gamma in a novel Neuromyelitis Optica Disease Spectrum Disorder animal model
Gabriel Arellano (USA)

2:15pm-2:30pm | #251 Pathogenic complement activation in myasthenia gravis depends on affinity matured autoantibodies with synergistic subunit specificities
Sebastian Holdermann (Switzerland)

2:30pm-2:45pm | #261 Single-cell phenotyping of B cells to investigate Rituximab response in patients with Myasthenia Gravis
Jacopo Morroni (Italy)

2:45pm-3:00pm | #3 The emerging role of autoreactive T cells in Guillain-Barré syndrome
Lenka Súkeníková (Switzerland)		Psychoneuroimmunology
Chairs: Jessica Deslauriers (Canada) & Frauke Zipp (Germany)

1:00pm-1:15pm | Immune-Brain Interactions in Depression
Scott Russo (USA)

1:15pm-1:30pm | Sex-specific brain and gut barrier alterations underlie stress vulnerability vs resilience in mice and human depression
Caroline Menard (Canada)

1:30pm-1:45pm | Using circadian neuroimmunology to dissect molecular, cellular, and functional outcomes in health and disease
Nader Ghasemlou (Canada)

Oral Presentations
1:45pm-2:00pm | #300 The presence of antibodies against muscarinic acetylcholine receptors in people with first episode psychosis predicts a worse clinical outcome at 12 months follow-up
Judith Greer (Australia)

2:00pm-2:15pm | #142 Interaction between a high fat diet and stress: effect on depression in relation to the gut microbiome-endocannabinoidome axis
Giada Giorgini (Canada)

2:15pm-2:30pm | Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge
Micaël Carrier (Canada)

2:30pm-2:45pm | #172 Psychological stress exacerbates immunoglobulin E-dependent chronic allergic skin inflammation via suppression of M2 macrophage-induced efferocytosis
Soichiro Yoshikawa (Japan)

2:45pm-3:00pm | #400 Neurovascular mitochondrial susceptibility impacts blood-brain barrier function and behavior
Jorge Alvarez (USA)		Learning about Neuroimmunology through MS
Sponsored by ACTRIMS
Chairs: Jacqueline Quandt (Canada) & Burkhard Becher (Switzerland)

1:00pm-1:24pm | An unexpected role of B cells in neuromyelitis optica
Thomas Korn (Germany)

1:24pm-1:48pm | Age-sensitive immune markers in multiple sclerosis: relation to biological sex and treatment response
Catherine Larochelle (Canada)

1:48pm-2:12pm | Decoding and targeting cell type-specific signatures underlying progressive neuroinflammation
Lucas Schirmer (Germany)

2:12pm-2:36pm | The Impact of Aging on Glia and Neuroinflammation: Implications for MS and EAE
Benjamin Segal (USA)

2:36pm - 3:00pm | Microglia in multiple sclerosis – pathogenesis and imaging
Laura Airas (Finland)

ISNI KEYNOTE LECTURE


3:15pm - 4:15pm
The Dale McFarlin Lecture
Chair: Jack Antel (Canada)

Tackling Heterogeneity in Multiple Sclerosis: On Path to Precision Neuroimmunology
Amit Bar-Or (USA)

POSTER SESSION 1


4:15pm - 6:15pm

Autoantibodies in neurological conditions
Immuno-neuro-oncology
Inflammation in neurodegenerative diseases
Non-MS autoimmune diseases
Psychoneuroimmunology
Biomarkers of neuroinflammation

Welcome Cocktail


6:15pm - 7:15pm